I did have several loops running and I had loaded some large loops (basically music videos, not that I use alot of them but M8 makes them look so damn cool). However, it was like M8 wasn't deactivating them when I loaded new loops in. I mean, say I load a 300 meg (uncompressed memory usage) loop into layer 1, does M8 give up the memory when I load a new loop into that layer or does it keep the 300 meg file in memory for future use (from my experience, that seems like what is happening).
In any case, I will have to go through and tune the memory usage on some of my loops. I'll probably switch the larger ones to compressed memory since that doesn't seem to incur much of a performance penalty on my machine.